Our lab is committed to supporting OSU’s strategic initiatives, focusing on areas such as climate solutions, robotics, clean energy, and biotechnology enhance integrated health. We strive for impactful research that fosters innovation and promotes sustainability in all our endeavors. Together, we aim to create a positive change for the future.
Biomaterials
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Our lab explores the design and application of cutting-edge biomaterials to support tissue regeneration and repair. By leveraging advanced fabrication techniques such as 3D bioprinting, electrospinning, and hydrogel synthesis, we develop scaffolds tailored to mimic native extracellular matrices. Our work focuses on applications in bone, cardiovascular, and neural tissue engineering.
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Cardiac Tissue Engineering
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We are advancing the frontiers of cardiac repair and regeneration through the development of 3D bioprinted cardiac tissue constructs. Our research focuses on designing bioinks and scaffolds that support the differentiation of stem cells into cardiomyocytes and the formation of functional cardiac tissue. By incorporating mechanical and electrical stimulation in bioreactors, we aim to replicate the native cardiac microenvironment, improving tissue maturation and functionality. These efforts are directed toward creating tissue-engineered grafts for myocardial repair and in vitro models for studying cardiac diseases.
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Bone Tissue Engineering
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We focus on developing innovative solutions for regenerating damaged or diseased bone. Our research includes designing biomaterial scaffolds, such as bioceramics, composites, and hydrogels, tailored to support osteogenesis and enhance structural integrity. Using advanced fabrication techniques like electrospinning, 3D bioprinting, we create scaffolds that closely mimic the native bone extracellular matrix. By integrating growth factors and stem cells, we aim to develop clinically translatable therapies for bone defects and orthopedic applications.
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Neural Tissue Engineering​​
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Our lab investigates strategies to repair and regenerate neural tissue by engineering biomimetic environments conducive to neuronal growth. We develop electrospun nanofibrous scaffolds and hydrogels designed to support neural progenitor cell differentiation and integration. Current projects include creating in vitro models for neurodegenerative diseases like Parkinson’s, studying neuron-glia interactions, and exploring the role of electrical and biochemical cues in promoting functional neural networks. Our work aims to advance regenerative therapies for spinal cord injuries and neurological disorders.
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Gastrointestinal Tissue Engineering
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We focus on creating in vitro 3D models for disease studies, exploring host-microbiome interactions, and advancing platforms for drug screening and tissue repair to address gastrointestinal disorders.
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Lab-Grown Meat
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We are at the forefront of cellular agriculture, striving to revolutionize the food industry by engineering lab-grown meat. Our research involves optimizing scaffolds, bioinks, and bioreactor designs to support the growth and differentiation of bovine muscle and adipose stem cells. By integrating biomimicry and advanced biomanufacturing, we aim to produce sustainable, ethical, and nutritionally superior alternatives to conventional meat.